Substituted coumarins as potent 5-lipoxygenase inhibitors

…, J Guay, P Hamel, D Riendeau, C Soucy-Breau…

Index: Grimm, Erich L.; Brideau, Christine; Chauret, Nathalie; Chan, Chi-Chung; Delorme, Daniel; Ducharme, Yves; Ethier, Diane; Falgueyret, Jean-Pierre; Friesen, Richard W.; Guay, Jocelyne; Hamel, Pierre; Riendeau, Denis; Soucy-Breau, Chantal; Tagari, Philip; Girard, Yves Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 9 p. 2528 - 2531

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Citation Number: 39

Abstract

Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure–activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.