European journal of medicinal chemistry

Inhibition of cyclic nucleotide phosphodiesterases from bovine aorta by papaverine analogues: a multivariate approach

C Lugnier, JC Dore, C Viel

Index: Prudhommeaux; Ernouf; Foussard Blanpin; Viel European Journal of Medicinal Chemistry, 1975 , vol. 10, # 1 p. 19 - 28

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Citation Number: 7

Abstract

Abstract In order to access relationships between the chemical structure of papaverine and 28 isoquinolic analogues and their enzymatic activity toward 3 types of cyclic phosphodiesterases (cAMP-PDE, cGMP-PDE, calmodulin-PDE), we used mathematical