Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src
M Cushman, H Zhu, RL Geahlen…
Index: Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J. Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
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Citation Number: 108
Abstract
A series of nitroflavones, 8a-p, and their corresponding aminoflavone hydrochloride salts, loa-p, was synthesized. The preparation of nitroflavones 8b-i, o, p began with commercially available o-hydroxyacetophenones 2b-f which were converted to o- hydroxynitroacetophenones 3a-h via a variety of nitration methods, followed by condensation with nitrobenzoyl chlorides and cyclization under acidic condition. The ...
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