Copper (II) bromide as an efficient catalyst for the selective protection and deprotection of alcohols as bis (4-methoxyphenyl) methyl ethers
…, YA Dembelé, Y Bikard, JM Weibel, A Blanc, P Pale
Index: Mezaache, Rofia; Dembele, Yenimegue Albert; Bikard, Yann; Weibel, Jean-Marc; Blanc, Aurelien; Pale, Patrick Tetrahedron Letters, 2009 , vol. 50, # 52 p. 7322 - 7326
Full Text: HTML
Citation Number: 21
Abstract
In a cheap and eco-friendly process, primary and secondary alcohols were easily protected as bis (methoxyphenyl) methyl (BMPM) ethers in good yields using CuBr2 as a catalyst in acetonitrile at room temperature. Deprotection could easily be achieved using the same catalyst but in ethanol. Both Cu-catalyzed protection and deprotection were orthogonal to other methods and fully compatible with other functional groups.
Related Articles:
[Kiddle, James J.; Green, Diana L. C.; Thompson, Charles M. Tetrahedron, 1995 , vol. 51, # 10 p. 2851 - 2864]
[Specklin, Simon; Gallier, Florian; Mezaache, Rofia; Harkat, Hassina; Dembele, Yenimegue Albert; Weibel, Jean-Marc; Blanc, Aurelien; Pale, Patrick Tetrahedron Letters, 2011 , vol. 52, # 44 p. 5820 - 5823]
Traceless solid-phase synthesis of hydroxylated cyclopentenones
[Stathakis, Christos I.; Gallos, John K. Tetrahedron Letters, 2008 , vol. 49, # 48 p. 6804 - 6806]
[Xu, Yanfen; Tang, Shouchu; Han, Junjie; She, Xuegong; Pan, Xinfu Tetrahedron Letters, 2008 , vol. 49, # 22 p. 3634 - 3637]
[Xu, Yanfen; Tang, Shouchu; Han, Junjie; She, Xuegong; Pan, Xinfu Tetrahedron Letters, 2008 , vol. 49, # 22 p. 3634 - 3637]