Isolation, synthesis and antitumor evaluation of spirohydantoin aziridine, a mutagenic metabolite of spirohydantoin mustard

RF Struck, MC Kirk, LS Rice…

Index: Struck, Robert F.; Kirk, Marion C.; Rice, Louise S.; Suling, William J. Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1319 - 1321

Full Text: HTML

Citation Number: 33

Abstract

SHAZ by synthesis from spirohydantoin and bis (2-chloroethy1)-amine. The metabolite and synthetic SHAZ cochromatographed in the solvent systems listed above. The mutagenicity of a sample of TLC-isolated metabolite and synthetic SHAZ was determined using Salmonella typhimurium strain TA1535 and a plate incorporation assay in the absence of S9. 4 The results are shown in Table I.