Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis

PR Carlier, YF Han, ESH Chow, CPL Li, H Wang…

Index: Carlier, Paul R.; Han, Yi Fan; Chow, Ella S.-H.; Li, Crystal P.-L.; Wang, Hong; Xuan Lieu, Thuy; Sum Wong, Hau; Pang, Yuan-Ping Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 2 p. 351 - 357

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Citation Number: 155

Abstract

To provide a further test of the dual binding site hypothesis proposed for acetylcholinesterase (AChE) inhibitor heptylene-linked bis-(9-amino-1, 2, 3, 4- tetrahydroacridine) A7A, short-tether (ethylene–hexylene) homologs A2A–A6A were prepared. En route to these compounds, convenient and scaleable syntheses of useful pharmaceutical intermediate 9-chloro-1, 2, 3, 4-tetrahydroacridine 3 and A7A were ...