Highly Regio??and Enantioselective Reduction of 3, 5??Dioxocarboxylates

M Wolberg, W Hummel, C Wandrey…

Index: Wolberg, Michael; Hummel, Werner; Wandrey, Christian; Mueller, Michael Angewandte Chemie - International Edition, 2000 , vol. 39, # 23 p. 4306 - 4308

Full Text: HTML

Citation Number: 141

Abstract

Abstract Only the keto group in position C-5 is reduced in the enzymatic reduction of 3, 5- dioxocarboxylates by the alcohol dehydrogenase of Lactobacillus brevis (LBADH; see scheme). The strategy of nature for manipulating β-keto metabolites inspired the development of a chemoenzymatic approach to virtually enantiopure 3, 5- dihydroxycarboxylate building blocks. The crucial enzymatic step can be performed on an ...