CuI-catalyzed intramolecular cyclization of 3-(2-aminophenyl)-2-bromoacrylate: synthesis of 2-carboxyindoles

X Xiao, TQ Chen, J Ren, WD Chen, BB Zeng

Index: Xiao, Xiong; Chen, Tian-Qi; Ren, Jiangmeng; Chen, Wei-Dong; Zeng, Bu-Bing Tetrahedron Letters, 2014 , vol. 55, # 13 p. 2056 - 2060

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Citation Number: 3

Abstract

2-Carboxyindole moiety was an important heterocyclic system in the nature products as well as a number of synthetic drugs. This type of compounds attracted more attention because of their various potential bioactivities such as antifungal, antibacterial, cytotoxic, and neuroregulation (Fig. 1). 1 More than ten efficient synthetic methods approaching indole-2-carboxylic acid ester have been reported 2 using metal-catalyzed coupling approaches and the azides ...