Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis

…, GD Coxon, SP Mackay, DE Minnikin, GS Besra

Index: Bhowruth, Veemal; Brown, Alistair K.; Reynolds, Robert C.; Coxon, Geoffrey D.; Mackay, Simon P.; Minnikin, David E.; Besra, Gurdyal S. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4743 - 4747

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Citation Number: 34

Abstract

Symmetrical and unsymmetrical analogues of the antimycobacterial agent isoxyl-have been synthesized and tested against Mycobacterium tuberculosis H37Rv and Mycobacterium bovis BCG, some showing an increased bactericidal effect. In particular, compounds 1-(pn- butylphenyl)-3-(4-propoxy-phenyl) thiourea (10) and 1-(pn-butylphenyl)-3-(4-n-butoxy- phenyl) thiourea (11) showed an approximate 10-fold increase in in vitro potency ...