Substituted Amides and Hydrazides of Dicarboxylic Acids. Part 11.1 Synthesis and Pharmacological Activity of a Series of Pyridylamides of Dicarboxylic Acids

…, NV Kolotova, VO Koz'minykh, BY Syropyatov

Index: Dolzhenko; Kolotova; Koz'minykh; Syropyatov Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 3 p. 125 - 127

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Abstract

Previously [1, 2], we have found compounds producing a hypertensive effect in pyridylamides of some dicarboxylic acids. Below we report on the synthesis of a series of new pyridylamides of succinic (Ia–IIIa), maleic (Ib–IIIb), and phthalic (Ic–IIIc) acids and attempts at establishing a relationship between the hypertensive activity and structure of these compounds.