Synthesis and cytotoxicity evaluation of 1-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]-3-aryl-1H-pyrazole-5-carboxylic acid derivatives

L Nagarapu, HK Gaikwad, K Sarikonda, J Mateti…

Index: Nagarapu, Lingaiah; Gaikwad, Hanmant K.; Sarikonda, Kartheeka; Mateti, Jhansi; Bantu, Rajashaker; Raghu; Manda, Krishna Madhuri; Kalvendi, Shasi Vardhan European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 4720 - 4725

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Citation Number: 31

Abstract

Several novel molecules, 1-(3′-(9H-carbazol-4-yloxy)-2′-hydroxypropyl)-3-aryl-1H- pyrazole-5-carboxylic acid derivatives 3a–g were synthesized and screened to evaluate their cytotoxicity against cancer cells in vitro. The compounds 3a–g has been prepared by the reaction of ethyl 3-aryl-1H-pyrazole-5-carboxylate with 4-oxiranylmethoxy-9H-carbazole in moderate to excellent yields. The cytotoxicity of synthesized compounds was evaluated ...