Incremental Solvation Precedes Ion??Pair Separation in Enantiomerization of a Cyano??Stabilized Grignard Reagent

NN Patwardhan, M Gao…

Index: Patwardhan, Neeraj N.; Gao, Ming; Carlier, Paul R. Chemistry - A European Journal, 2011 , vol. 17, # 44 p. 12250 - 12253

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Citation Number: 10

Abstract

Configurationally stable enantioenriched organolithium compounds are important in asymmetric synthesis.[1] Studies of the enantiomerization pathways of these compounds are useful for improving the stereochemical outcome of these reactions, and provide insight into the structure and dynamics of these compounds.[1a, f, 2] The composition of the organic fragment,[1a, f, 2a, d] the presence of additives,[2d, 3] and the identity of the solvent [2d, 4] ...