Novel intramolecular rearrangement of 5-carbamoyluraclls into barbituric acids

K Hirota, H Sajiki, PZ Ni, Y Kitade, Y Maki

Index: Hirota; Sajiki; Ni; Kitade; Maki Tetrahedron, 1990 , vol. 46, # 10 p. 3431 - 3438

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Citation Number: 4

Abstract

Heating of 5-carbamoyl-(1) and 5-thiocarbamoyl-3-methyl-1-phenyluracil (5) derivatives in ethanolic sodium ethoxide causes a novel intramolecular rearrangement to give 5- anilinomethylenebarbituric acids (2) and 5-anilinomethylene-4-thiobarbituric and (6), respectively.