Design, synthesis, and antihepatitis B virus activities of novel 2-pyridone derivatives

…, C Sheng, T Wang, Y Zhang, J Liu, J Feng…

Index: Lv, Zhiliang; Sheng, Chunquan; Wang, Tiantian; Zhang, Yikai; Liu, Jia; Feng, Jilu; Sun, Hailing; Zhong, Hanyu; Niu, Chunjuan; Li, Ke Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 660 - 668

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Citation Number: 43

Abstract

A series of novel 2-pyridone derivatives were synthesized and evaluated for their antihepatitis B virus (HBV) activity and cytotoxicity in vitro. Moderate to good activity against HBV DNA replication was observed in these 2-pyridone analogues. The most active compounds were 5d and 6l, with good inhibitory activity against HBV DNA replication (IC50= 0.206 and 0.12 μM, respectively) and remarkable high selectivity (selectivity indexes of> ...