Anorexigenic agents: aromatic substituted 1-phenyl-2-propylamines

GF Holland, CJ Buck, A Weissman

Index: Holland,G.F. et al. Journal of Medicinal Chemistry, 1963 , vol. 6, p. 519 - 524

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Citation Number: 40

Abstract

A number of aromatic substituted 1-phenyl-2-propylamines (Table I) have been prepared by three general routes. The anorectic activities of these compounds are listed in Table IV. Although none are as active as (+)-amphetamine, a number are more potent than phenmetrazine or diethylpropion. The most active compounds are 1-(4- dimethylaminophenyl)-2-propylamine and l-(3-trifluoromethylphenyl)-2-propylaniine. ...