Tetrahedron letters

Synthesis of 2-oxazolines mediated by N, N′-diisopropylcarbodiimide

S Crosignani, AC Young, B Linclau

Index: Crosignani, Stefano; Young, Abigail C.; Linclau, Bruno Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9611 - 9615

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Citation Number: 31

Abstract

N-(β-Hydroxy) amides can be cyclised by reaction with diisopropylcarbodiimide (DIC) to give the corresponding 2-oxazolines in high yields. The reaction requires only very mild Lewis- acid catalysis (5mol% Cu (OTf) 2) and can be accomplished with simple heating, or in very short reaction times under microwave irradiation.

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