Novel azapeptide inhibitors of hepatitis C virus serine protease

…, T Halmos, N Goudreau, E Lescop…

Index: Bailey, Murray D.; Halmos, Ted; Goudreau, Nathalie; Lescop, Ewen; Llinas-Brunet, Montse Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3788 - 3799

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Citation Number: 36

Abstract

Azapeptides are known inhibitors of several serine and cysteine proteases. In seeking different classes of inhibitors for the HCV serine protease, a series of novel azapeptide- based inhibitors were investigated which incorporated noncleavable P1/P1'aza-amino acyl residues. Extensive SAR studies around the P1/P1'aza-amino acyl fragment resulted in the identification of potent and selective inhibitors. Using NMR studies, we have shown that ...