Na+-Glucose Cotransporter Inhibitors as Antidiabetic Agents. II. Synthesis and Structure-Activity Relationships of 4'-Dehydroxyphlorizin Derivatives.

…, T Tanaka, N Funami, K SAITO, K ARAKAWA…

Index: Hongu, Mitsuya; Tanaka, Takashi; Funami, Nobuyuki; Saito, Kunio; Arakawa, Kenji; Matsumoto, Mamoru; Tsujihara, Kenji Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 1 p. 22 - 33

Full Text: HTML

Citation Number: 41

Abstract

A novel series of 4'-dehydroxyphlorizin derivatives was synthesized and the effects of these compounds on urinary glucose excretion were evaluated in rats. There was a strict structural requirement for activity. Introduction of a small substituent or a flat ring at the 3-and/or the 4- position on the A ring was permissible, but any change at the bridge part between the A and B rings or in the sugar moiety resulted in complete loss of activity. The 6'-OH group on the ...