A one-pot isomerization-arylation of 2, 3-epoxycyclohexanone under controlled microwave heating

…, N Garg, P Nilsson, A Hallberg, M Larhed

Index: Svennebring, Andreas; Garg, Neeraj; Nilsson, Peter; Hallberg, Anders; Larhed, Mats Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4720 - 4725

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Citation Number: 25

Abstract

A fast one-pot method has been developed for the direct preparation of 3-aryl-1, 2- cyclohexanediones from 2, 3-epoxycyclohexanone via a microwave-assisted tandem epoxy ketone isomerization-Heck arylation reaction. The preparative microwave-assisted reactions were performed preferentially in 50% aqueous poly (ethylene glycol) utilizing sodium acetate as the base. Within 5-30 min of directed microwave heating, employing less than ...