One-pot α-nucleophilic fluorination of acetophenones in a deep eutectic solvent
Z Chen, W Zhu, Z Zheng, X Zou
Index: Chen, Zizhan; Zhu, Wei; Zheng, Zubiao; Zou, Xinzhuo Journal of Fluorine Chemistry, 2010 , vol. 131, # 3 p. 340 - 344
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Citation Number: 42
Abstract
Two methods of nucleophilic fluorination to prepare α-fluoroacetophenones from α- bromoacetophenones by using KF with PEG-400 or TBAF with ZnF2 are described. On the fundamental of nucleophilic fluorination, a novel method of one-pot fluorination to prepare α- fluoroacetophenones directly from acetophenones in DES was developed.
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