The Journal of organic chemistry

Practical and simple synthesis of substituted quinolines by an HCl-DMSO system on a large scale: Remarkable effect of the chloride ion

S Tanaka, M Yasuda, A Baba

Index: Tanaka, Shin-Ya; Yasuda, Makoto; Baba, Akio Journal of Organic Chemistry, 2006 , vol. 71, # 2 p. 800 - 803

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Citation Number: 60

Abstract

A variety of substituted quinolines are synthesized from imines and enolizable carbonyl compounds under aerobic conditions, in which only water is a byproduct. In DMSO, a catalytic amount of HCl activates carbonyl compounds quite effectively to give the quinolines. A simple and practical procedure is demonstrated on a large scale.

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