Synthesis of oligonucleotides containing 2′-deoxyguanosine adducts of nitropyrenes

…, D Chakraborti, P Hilario, C McCarty…

Index: Colis, Laureen C.; Chakraborti, Debasis; Hilario, Pablo; McCarty, Christopher; Basu, Ashis K. Nucleosides, Nucleotides and Nucleic Acids, 2009 , vol. 28, # 2 p. 67 - 77

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Citation Number: 6

Abstract

Two different approaches to synthesize oligonucleotides containing the 2′- deoxyguanosine adducts formed by nitropyrenes are described. A direct reaction of an unmodified oligonucleotide with an activated nitropyrene derivative is a convenient biomimetic approach for generating the major adducts in DNA. A total synthetic approach, by contrast, involves several synthetic steps, including Buchwald-Hartwig Pd-catalyzed ...