Facile synthesis of 3'-O-methylthymidine and 3'-deoxythymidine and related deoxygenated thymidine derivative: a new method for selective deoxygenation of …
M Sekine, T Nakanishi
Index: Sekine, Mitsuo; Nakanishi, Takeshi Journal of Organic Chemistry, 1990 , vol. 55, # 3 p. 924 - 928
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Citation Number: 31
Abstract
This paper deals with convenient syntheses of 3'-0-methylthymidine (2) and 3'- deoxythymidine (3), which involve AgzO-promoted methylation and Barton-Robins reductive deoxygenation, respectively. New methods for the regioselective 3'-and 5'-deoxygenation of thymidine have also been developed. Namely, compound 3 was synthesized by the 3', 5'-O- diacylation of thymidine with phenyl chlorothionoformate (PTCF) followed by the selective ...
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