Tetrahedron

Preparation of aminals in water

V Jurčı́k, R Wilhelm

Index: Jurcik, Vaclav; Wilhelm, Rene Tetrahedron, 2004 , vol. 60, # 14 p. 3205 - 3210

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Citation Number: 33

Abstract

Aminals, which are used as protecting groups in syntheses and are part of many biologically active compounds, are normally prepared from aldehydes and diamines under conditions that remove water in order to shift the equilibrium to the side of the aminal. Here we report for the first time that aminals can be prepared and isolated in pure water without a catalyst in high yield and purity.