Highly efficient dialkylphosphate-mediated syntheses of hydantoins and a bicyclohydantoin under solvent-free conditions
V Kumar, H Rana, R Sankolli, MP Kaushik
Index: Kumar, Vinod; Rana, Hemlata; Sankolli, Ravish; Kaushik Tetrahedron Letters, 2011 , vol. 52, # 46 p. 6148 - 6151
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Citation Number: 11
Abstract
Diversely substituted hydantoins have been synthesized by new strategy from cyanamide based precursor, that is, methyl N-cyano-N-alkyl/arylaminoacetate. Dialkylphosphates were employed as the mild reagent to hydrolyze and cyclize the substrate in one step to give quantitative yields of the desired products. Syntheses of multivalent hydantoins viz bis- hydantoin, bicyclohydantoin have potentially widened the scope and applicability of the ...
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