The preparation of N-carboxyanhydrides of α-amino acids using bis (trichloromethyl) carbonate
WH Daly, D Poché
Index: Daly, William H.; Poche, Drew Tetrahedron Letters, 1988 , vol. 29, # 46 p. 5859 - 5862
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Citation Number: 548
Abstract
Abstract A synthesis of the N-carboxyanhydrides (NCA's) of several α-amino acids using bis (trichloromethyl) carbonate, 1, is reported. The triphosgene is used to supply phosgene in situ in stoichiometric amounts; it is particularly effective for preparing NCA's of amino acids with long, aliphatic side chains.
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