Regio-and stereoselective synthesis of the major metabolite of quercetin, quercetin-3-O-β-d-glucuronide
M Bouktaib, A Atmani, C Rolando
Index: Bouktaib, Mohamed; Atmani, Aziz; Rolando, Christian Tetrahedron Letters, 2002 , vol. 43, # 35 p. 6263 - 6266
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Citation Number: 99
Abstract
Protected quercetin was first transformed selectively in its 3-O-β-d-glucoside. Further protection of the remaining phenolic hydroxyl group allows a clean oxidation of the glucoside by TEMPO/NaOCl/NaBr under phase transfer conditions into the corresponding glucuronide which was cleanly deprotected to quercetin-3-O-β-d-glucuronide.
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