Antimalarial activity of guanylhydrazone salts of aromatic ketones. 2. Development of active polyhalo derivatives

FA French, JR DoAmaral, EJ Blanz Jr…

Index: DoAmaral,J.R. et al. Journal of Medicinal Chemistry, 1971 , vol. 14, p. 862 - 866

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Citation Number: 12

Abstract

Twenty-four guanylhydrazones of polyhalo-substituted benzophenones were synthesized and tested in the primary antimalarial screen in mice infected with P/asmodium brrghei..% 11 cornpds but one bore halo or halogen-containing substituents on both rings. The minimum requirement for activity within t. his context. is t, he presence of a CF3 group in the 3 or 4 position or a FSCO group in the 4 position on one ring and halo or CFa in the 3 or 4 ...