Total Synthesis of (18S)??and (18R)??Homolargazole by Rhodium??Catalyzed Hydrocarboxylation

…, D Ostrovskyi, J Senger, K Schmidtkunz…

Index: Schotes, Christoph; Ostrovskyi, Dmytro; Senger, Johanna; Schmidtkunz, Karin; Jung, Manfred; Breit, Bernhard Chemistry - A European Journal, 2014 , vol. 20, # 8 p. 2164 - 2168

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Citation Number: 10

Abstract

Abstract Homolargazole derivatives, in which the macrocycle of natural largazole is extended by one methylene group, were prepared by the recently developed rhodium- catalyzed hydrocarboxylation reaction onto allenes. This strategy gives access to both the (18S)-and (18R)-stereoisomers in high stereoselectivity under ligand control.