Studies on condensed pyrimidine systems. XIX. A new synthesis of pyrido [2, 3-d] pyrimidines. The condensation of 1, 3-diketones and 3-ketoaldehydes with 4- …

RK Robins, GH Hitchings

Index: Robins; Hitchings Journal of the American Chemical Society, 1958 , vol. 80, p. 3449,3454

Full Text: HTML

Citation Number: 57

Abstract

In addition, 5, 7-dimethyl-4-hydroxypyrido[2, 3-d]-pyrimidine was prepared by the alternate method from 2-amino-4, 6-dimethyl-3-pyridinecarboxylic acid. Finally, 2, 4-dihydroxypyrido [2, 3-d] pyrimidine was synthesized from 6-aminouracil and shown to be identical to this substance as prepared earlier from 2-aminonicotinic acid.* Variations in the dicarbonyl reagent were investigated next. It was soon discovered that alkylated derivatives of ...