Imidazopyridine-5, 6, 7, 8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1

…, A Spaltenstein, M Thomson, P Wheelan…

Index: Gudmundsson, Kristjan S.; Boggs, Sharon D.; Catalano, John G.; Svolto, Angilique; Spaltenstein, Andrew; Thomson, Michael; Wheelan, Pat; Jenkinson, Stephen Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 22 p. 6399 - 6403

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Citation Number: 38

Abstract

Synthesis of several novel imidazopyridine-5, 6, 7, 8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity and pharmacokinetics are highlighted. Several compounds with low nanomolar anti-HIV activity and oral bioavailability are described.