1-[4-(3-Phenylalkyl) phenyl]-2-aminopropanes as 5-HT2A partial agonists

…, K Herrick-Davis, C Egan, A DuPre…

Index: Metwally, Kamel A.; Dukat, Malgorzata; Egan, Christina T.; Smith, Carol; DuPre, Ann; Gauthier, Colleen B.; Herrick-Davis, Katharine; Teitler, Milt; Glennon, Richard A. Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 5084 - 5093

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Citation Number: 27

Abstract

Phenylalkylamines such as 1-(4-bromo-2, 5-dimethoxyphenyl)-2-aminopropane (DOB; 1a) and its corresponding iodo derivative DOI (2) are commonly used 5-HT2 serotonin agonists. Previous studies have established that the 2, 5-dimethoxy substitution pattern found in these compounds is optimal for high affinity at 5-HT2A receptors and that substituents at the 4- position can modulate affinity over a wide range. We have previously shown, however, ...