An Efficient Palladium??NHC (NHC= N??Heterocyclic Carbene) and Aryl Amination Pre??Catalyst:[Pd (IPr*)(cinnamyl) Cl]

A Chartoire, X Frogneux…

Index: Chartoire, Anthony; Frogneux, Xavier; Nolan, Steven P. Advanced Synthesis and Catalysis, 2012 , vol. 354, # 10 p. 1897 - 1901

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Citation Number: 40

Abstract

Abstract The well-defined [Pd (IPr*)(cinnamyl) Cl] complex is reported as one of the best N- heterocyclic carbene (NHC)-based pre-catalysts for the Buchwald–Hartwig amination reaction. This catalytic system displays high efficiency for the coupling of numerous (hetero) aryl chlorides, with a wide range of amines, at room temperature or at extremely low catalyst loading (as low as 0.025 mol%).