Asymmetric preparation of antifungal 1-(4′-chlorophenyl)-1-cyclopropyl methanol and 1-(4′-chlorophenyl)-2-phenylethanol. Study of the detoxification mechanism …

…, R Hernández-Galán, J Aleu, IG Collado

Index: Pinedo-Rivilla, Cristina; Bustillo, Antonio J.; Hernandez-Galan, Rosario; Aleu, Josefina; Collado, Isidro G. Journal of Molecular Catalysis B: Enzymatic, 2011 , vol. 70, # 1-2 p. 61 - 66

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Abstract

Chiral alcohols are important as bioactive compounds or as precursors to such molecules. On the basis of the different antifungal properties of the enantiopure alcohol derivatives of 4′-chlorophenyl cyclopropyl ketone and benzyl 4′-chlorophenyl ketone, their enantioselective synthesis by chemical and biocatalytic methods was studied. The detoxification pathways by the phytopathogen fungus Botrytis cinerea are reported.