Selective Olefin Reduction in Thebaine Using Hydrazine Hydrate and O2 under Intensified Continuous Flow Conditions

B Pieber, DP Cox, CO Kappe

Index: Lamani, Manjunath; Guralamata, Ravikumara Siddappa; Prabhu, Kandikere Ramaiah Chemical Communications, 2012 , vol. 48, # 52 p. 6583 - 6585

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Abstract

... thebaine in 1968 providing hydrocodone (1) in good isolated yield (79%) after 48 h.(12 ... A promising alternative circumventing these boundaries is the use of continuous flow chemistry.(14, 15 ... 17) As a result water and nitrogen are formed as only benign chemical byproducts often ...