Formal asymmetric biocatalytic reductive amination

D Koszelewski, I Lavandera, D Clay…

Index: Koszelewski, Dominik; Lavandera, Ivan; Clay, Dorina; Guebitz, Georg M.; Rozzell, David; Kroutil, Wolfgang Angewandte Chemie - International Edition, 2008 , vol. 47, # 48 p. 9337 - 9340

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Citation Number: 185

Abstract

Asymmetric methods to prepare optically active a-chiral primary amines are highly demanded in asymmetric synthesis owing to the biological/pharmacological activity of many amines.[1] Various techniques have been reported, such as asymmetric 1, 2-addition to imines and asymmetric amination of a, a-disubstituted aldehydes,[2] transformation of allylic alcohols into amines,[3](dynamic) kinetic resolution,[4] and cyclic deracemization [5] ...