A convenient method for the preparation of chiral phosphonoacetamides and their Horner–Wadsworth–Emmons reaction

…, M Fernández-Zertuche, O García-Barradas

Index: Ordonez, Mario; Hernandez-Fernandez, Eugenio; Montiel-Perez, Martin; Bautista, Rafael; Bustos, Paola; Rojas-Cabrera, Haydee; Fernandez-Zertuche, Mario; Garcia-Barradas, Oscar Tetrahedron Asymmetry, 2007 , vol. 18, # 20 p. 2427 - 2436

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Citation Number: 18

Abstract

Chiral phosphonoacetamides bearing (S)-(α-methylbenzyl) benzylamine,(S, S)-bis (α- methylbenzyl) amine, l-phenylglycine methyl ester and l-phenylglycinol were easily prepared in good yield by means of the Michaelis–Arbuzov reaction of chiral bromoacetamides obtained in quantitative yield, with trimethyl phosphite, which under Horner–Wadsworth–Emmons conditions with several aryl and alkyl aldehydes under ...