The Journal of organic chemistry

… of an Ester Derivative of the Procarcinogen and Promutagen, PhIP, 2-Amino-1-methyl-6-phenyl-1 H-imidazo [4, 5-b] pyridine: Unusual Nitrenium Ion Chemistry

TM Nguyen, M Novak

Index: Nguyen, Thach-Mien; Novak, Michael Journal of Organic Chemistry, 2007 , vol. 72, # 13 p. 4698 - 4706

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Citation Number: 15

Abstract

The food-derived heterocyclic amine (HCA) carcinogen 2-amino-1-methyl-6-phenyl-1 H- imidazo [4, 5-b] pyridine, PhIP, is often generated in the highest concentration of the HCAs formed during broiling and frying of meat and fish. Although it is considered to be an important contributor to human cancer risk from exposure to HCAs, the chemistry of PhIP metabolites that presumably react with DNA to initiate carcinogenesis has received only ...