The Journal of Organic Chemistry

HYCRON, an allylic anchor for high-efficiency solid phase synthesis of protected peptides and glycopeptides

O Seitz, H Kunz

Index: Seitz, Oliver; Kunz, Horst Journal of Organic Chemistry, 1997 , vol. 62, # 4 p. 813 - 826

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Citation Number: 105

Abstract

The recently developed allylic HYCRON anchor1 exhibits excellent properties for the solid phase synthesis of protected peptides and glycopeptides. Model reactions with analogous low molecular weight compounds assessed the acid-and base-stability of the polar and flexible HYCRON linkage. The new anchor is available in a two-step synthesis and allows the use of both the Boc-and the Fmoc-strategy, which can even be combined within one ...