A novel, highly selective, and general methodology for the synthesis of 1, 5-diene-containing oligoisoprenoids of all possible geometrical combinations exemplified by …

E Negishi, SY Liou, C Xu, S Huo

Index: Negishi, Ei-Ichi; Liou, Show-Yee; Xu, Caiding; Huo, Shouquan Organic Letters, 2002 , vol. 4, # 2 p. 261 - 264

Full Text: HTML

Citation Number: 93

Abstract

A truly general, versatile, and highly regio-and stereoselective methodology for the synthesis of terpenoids containing 1, 5-diene units of E and/or Z geometry critically involves Pd- catalyzed homoallyl-and homopropargyl-alkenyl coupling and Zr-catalyzed carboalumination of alkynes. By using this methodology, coenzyme Q10,(E, Z, E)- geranylgeranoil, and other natural or unnatural compounds have been synthesized ...