Synthesis and bioacceptability of fluorinated surfactants derived from F-alkylated tertiary amines

JB Nivet, R Bernelin, M Le Blanc, JG Riess

Index: Nivet; Bernelin; Le Blanc; Riess European Journal of Medicinal Chemistry, 1992 , vol. 27, # 9 p. 891 - 898

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Citation Number: 8

Abstract

Abstract Two methods for synthesizing tertiary F-alkylated amines are reported. The more general method allows the access in 56–87% yields to various N, N-dialkyl F-alkyl amines. These amines are key intermediates leading in 52–96% yields to several families of surfactants, including zwitterionic and cationic derivatives and amine oxides, potentially useful in the formulation of fluorocarbon emulsions for diagnostic and therapeutic uses. ...