Synthesis and physico-chemical properties in aqueous medium of all possible isomeric bromo analogues of benzo-1H-triazole, potential inhibitors of protein kinases

…, P Wińska, J Poznański, D Shugar

Index: Wasik, Romualda; Winska, Patrycja; Poznanski, Jaroslaw; Shugar, David Journal of Physical Chemistry B, 2012 , vol. 116, # 24 p. 7259 - 7268

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Citation Number: 14

Abstract

In ongoing studies on the role of the individual bromine atoms of 4, 5, 6, 7- tetrabromobenzotriazole (TBBt) in its relatively selective inhibition of protein kinase CK2α, we have prepared all the possible two mono-, four di-, and two tri-bromobenzotriazoles and determined their physicochemical properties in aqueous medium. They exhibited a general trend of a decrease in solubility with an increase in the number of bromines on the ...