Chemistry Letters

A novel ethynylation of pyridines by Reissert-Henze type reaction.

N Nishiwaki, S Minakata, M Komatsu, Y Ohshiro

Index: Nishiwaki, Nagatoshi; Minakata, Satoshi; Komatsu, Mitsuo; Ohshiro, Yoshiki Chemistry Letters, 1989 , p. 773 - 776

Full Text: HTML

Citation Number: 12

Abstract

W6 GwmmnyLamm,1989 In all cases, the substitution occurred at 2— or 6—position and not at 4— position. Electron—withdrawing substituents raised the yields of ethynyl— pyridines. It was found that hitherto unknown polyfunctionalized ethynylpyridines can be easily prepared by this method.5) When the 3—substituted pyridine N—oxides were used as substrates, ethynyla— tion occurred at 2- and 6—positions, but 2—ethynylation was predominant in ...

Related Articles:

A new, efficient, and inexpensive copper (II)/salicylic acid complex catalyzed Sonogashira-type cross-coupling of haloarenes and iodoheteroarenes with terminal …

[Chen, Horung-Jyh; Lin, Zhe-Yi; Li, Meng-Yuan; Lian, Ruei-Jheng; Xue, Qing-Wen; Chung, Jui-Lun; Chen, Shu-Chih; Chen, Yao-Jung Tetrahedron, 2010 , vol. 66, # 39 p. 7755 - 7761]

A straightforward copper-free palladium methodology for the selective alkynylation of a wide variety of S-, O-, and N-based mono-and diheterocyclic bromides and …

[Saleh, Samer; Picquet, Michel; Meunier, Philippe; Hierso, Jean-Cyrille Tetrahedron, 2009 , vol. 65, # 34 p. 7146 - 7150]

Synthesis of 1, 2-disubstituted acetylenes via copper-catalyzed Suzuki coupling of organoboronic acids with 1, 1-dibromo-1-alkenes

[Liu, Jidan; Dai, Fenglin; Yang, Zhiyong; Wang, Sizhuo; Xie, Kai; Wang, Anwei; Chen, Xiang; Tan, Ze Tetrahedron Letters, 2012 , vol. 53, # 42 p. 5678 - 5683]

Synthesis of unsymmetrically disubstituted ethynes by the palladium/copper (I)-cocatalyzed sila-Sonogashira–Hagihara coupling reactions of alkynylsilanes with aryl …

[Nishihara, Yasushi; Inoue, Eiji; Noyori, Shintaro; Ogawa, Daisuke; Okada, Yoshiaki; Iwasaki, Masayuki; Takagi, Kentaro Tetrahedron, 2012 , vol. 68, # 24 p. 4869 - 4881]

Preparation of 3-substituted-2-pyridin-2-ylindoles: regioselectivity of Larock's indole annulation with 2-alkynylpyridines

[Roschangar, Frank; Liu, Jianxiu; Estanove, Emilie; Dufour, Marine; Rodriguez, Sonia; Farina, Vittorio; Hickey, Eugene; Hossain, Azad; Jones, Paul-James; Lee, Heewon; Lu, Bruce Z.; Varsolona, Richard; Schroeder, Juergen; Beaulieu, Pierre; Gillard, James; Senanayake, Chris H. Tetrahedron Letters, 2008 , vol. 49, # 2 p. 363 - 366]

More Articles...