Tetrahedron Letters

A convenient synthesis of hindered amines and α-trifluoromethylamines from ketones

CL Barney, EV Huber, JR McCarthy

Index: Barney, Charlotte L.; Huber, Edward V.; McCarthy, James R. Tetrahedron Letters, 1990 , vol. 31, # 39 p. 5547 - 5550

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Citation Number: 83

Abstract

Abstract Ketones and α-trifluoromethylketones were converted to primary, secondary, and tertiary amines in good to excellent yields by a reductive amination procedure utilizing TiCl 4/NaCNBH 3. The method provides the first direct route to α-trifluoromethylamines from ketones, and access to hindered amines from ketones which are unobtainable by Borch reducttve amination.