Molecules

An efficient synthesis of a spirocyclic oxindole analogue

D Teng, H Zhang, A Mendonca

Index: Teng, Dawei; Zhang, Hongxing; Mendonca Molecules, 2006 , vol. 11, # 9 p. 700 - 706

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Citation Number: 13

Abstract

Abstract: An efficient, scaleable synthesis approach towards the spirocyclic oxindole analogue 1'-(tert-butoxycarbonyl)-2-oxospiro [indoline-3, 4'-piperidine]-5-carboxylic acid (1) is described. The key steps are dianion alkylation and cyclization of ethyl 2-oxindoline-5- carboxylate (4) and demethylation of the resulting spirocyclic oxindoleethyl 1'-methyl-2- oxospiro [indoline-3, 4'-piperidine]-5-carboxylate (5). The target compound was obtained ...