Antihypertensive activity of 6-arylpyrido [2, 3-d] pyrimidin-7-amine derivatives

LR Bennett, CJ Blankley, RW Fleming…

Index: Bennett, Lawrence R.; Blankley, C. John; Fleming, Robert W.; Smith, Ronald D.; Tessman, Deirdre K. Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 382 - 389

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Citation Number: 44

Abstract

A series of 51 6-arylpyrido [2, 3-d] pyrimidin-7-amine derivatives was prepared and evaluated for antihypertensive activity in the conscious spontaneously hypertensive rat. A number of these compounds, notably 6-(2, 6-dichloro-phenyl)-2-methylpyrido [2, 3-d] pyrimidi-7-amine (36), lowered blood pressure in theae rata in a gradual and sustained manner to normotensive levels at oral doses of 10-50 mg/kg. Normalized blood pressure ...