An efficient synthesis of functionalized 2-pyridones by direct route or via amide/enolate ammonium salt intermediates

F Bondavalli, O Bruno, EL Presti, G Menozzi…

Index: Bondavalli; Bruno; Lo Presti; Menozzi; Mosti Synthesis, 1999 , # 7 p. 1169 - 1174

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Citation Number: 28

Abstract

Abstract: A number of compounds with a 2-pyridone structure 3, which have different substituents and are analogous to cardiotonic drugs like milrinone, have been synthesized in high yields from the appropriate enamino ketones 2 using different cyanomethylene active compounds (methyl cyanoacetate, benzoylacetonitrile and phenylsulfonylacetonitrile). In this synthetic route, the active role of the dimethylamine released in situ on the cyclization ...