Novel approach to the synthesis of 3-acyl substituted indolizines. The synthesis of 3-(indolizinyl-2) alanine and 4-(indolizinyl-3) homoalanine derivatives

…, U Bratušek, M Škof, J Svete, B Stanovnik

Index: Jukic, Lucija; Bratusek, Urska; Skof, Marko; Svete, Jurij; Stanovnik, Branko Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 11-12 p. 1295 - 1299

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Citation Number: 2

Abstract

Abstract A novel approach to the synthesis of 3-acylindolizines and the transformations of some acids into tryptophane analogues are described. Reaction of ethyl 2-pyridinylacetate and methyl 2-quinolinylacetate with N-trifluoroacetyl-5-bromo-4-oxonorvaline methylester led to N-trifluoroacetyl-3-(1-ethoxycarbonylindolizinyl-2) alanine methyl ester and N- trifluoroacetyl-3-(3-methoxycarbonylpyrrolo [1, 2-a] quinolinyl-2) alanine methyl ester, ...