Selective Palladium??Catalyzed Direct Arylation of Furo [3, 2??b] pyridines

…, JC Florent, E Bertounesque

Index: Carrr, Amandine; Florent, Jean-Claude; Bertounesque, Emmanuel; Rousselle, Patricia Advanced Synthesis and Catalysis, 2012 , vol. 354, # 14-15 p. 2751 - 2756,6

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Citation Number: 10

Abstract

Abstract A method for palladium-catalyzed direct arylation has been developed for the selective functionalization of the C-3 and C-7 positions of 2-substituted furo [3, 2-b] pyridines. An unconventional reactivity resulting from the annulation of a pyridine ring with a furan ring is outlined and results in an unprecedented C-7 [BOND] H bond activation. The role of the pivalic acid additive is rationalized by invoking a concerted metallation– ...