Synthesis of novel tetrahydroisoquinoline bronchodilators

MF Dalence-Guzmán, J Toftered, VT Oltner…

Index: Dalence-Guzman, Maria F.; Toftered, Joergen; Oltner, Viveca Thornqvist; Wensbo, David; Johansson, Martin H. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 4999 - 5003

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Citation Number: 8

Abstract

The synthesis and bronchorelaxing effects of a series of novel tetrahydroisoquinoline amides are described. The compounds were evaluated for their ability to relax LTD4 contracted isolated human small airways ex-vivo. Several compounds demonstrated highly efficacious bronchorelaxing properties. Cinnamide 71 was selected for further studies and constitutes a promising candidate as a novel bronchorelaxing agent for the treatment of ...